Developmental Stress – Health
Developmental Stress The Origins Of Adult Disease Andrea Danese MD MSc BACKGROUND WHAT WHEN HOW WHY CONCLUSIONS BACKGROUND WHAT WHEN HOW WHY CONCLUSIONS BACKGROUND What is inflammation INFLAMMATION Innate immunity Body physical barriers e g skin...
...stress THE EPIGENETIC LANDSCAPE ADULT DISEASE RISK EARLY EXPERIENCE HEALTH Genes TIME age Waddington CH 1975 E1 t1 E1 t2 E2 t3 STRESS SYMPATHETIC PARASYMPATHETIC GLUCOCORTICOIDS STRESS INFLAMMATION IN ADULTS WITH MALTREATMENT HISTORY STRESS SYMPATHETIC PARASYMPATHETIC GLUCOCORTICOIDS STRESS... vs GENETIC MISMATCH LIFE EXPECTANCY 1 million years ago 12 25 years Today about 80 years Kirkwood T 2000 Nature Straub R 2003 FASEB J Gluckman P 2004 Science The lengthening of human lifespan may have uncovered long term damaging...
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